Lubrizol LifeSciences Carbopol® 71G NF Polymer

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Lubrizol LifeSciences Carbopol® 71G NF Polymer
Categories:	Polymer; Thermoplastic
Material Notes:	Carbopol® 71G NF polymer meets the limits cited in the current edition of the following monographs: United States Pharmacopeia/National Formulary (USP/NF) monograph for Carbomer Homopolymer Type A European Pharmacopeia (Ph. Eur.) monograph for Carbomers India Pharmacopeia (IP) monograph for Carbomers China Pharmacopeia (ChP) monograph for Carbomers Class I solvents including benzene and 1,2 dichloroethane (to be avoided) and class II solvents including methylene chloride and cyclohexane (to be limited) per ICH Q3C guidance are NOT used as raw materials or in the production of this excipient. But in order to ensure compliance with USP/NF/Ph.Eur/IP/ChP monograph requirements, benzene is tested and reported. Information provided by Lubrizol
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Physical Properties	Original Value	Comments

Particle Size	150 µm	100 mesh, 150 min; ASTM D1921
	425 µm	40 mesh, 95 min; ASTM D1921
Brookfield Viscosity	4000 - 11000 cP	RVT, 20 rpm, neutralized to pH 7.3 - 7.8 0.5 wt% mucilage, spindle #5; Lubrizol 430-I
Ash	<= 2.5 %	Residue on Ignition; USP/NF

Descriptive Properties
Appearance	White granules
Carboxylic Acid Content, Assay	56-68%	Lubrizol 1318-A
Identification	Pass	1:200, Colorimetric test, USP/NF
	Pass	1:200, Gel formation test, USP/NF
	Pass	Infrared spectrum, Lubrizol SA-102
	Pass	1:200, Precipitate test, USP/NF
Loss on Drying	<2%	USP/NF
Odor	Slightly acetic
Residual Monomer	<1000 ppm	Free acrylic acid, Lubrizol SA-005
Residual Solvent	<0.5 %	Ethyl acetate, Lubrizol SA-009

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PLUBR8000 / 238948

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